منابع مشابه
Histone transfer among chaperones.
The eukaryotic processes of nucleosome assembly and disassembly govern chromatin dynamics, in which histones exchange in a highly regulated manner to promote genome accessibility for all DNA-dependent processes. This regulation is partly carried out by histone chaperones, which serve multifaceted roles in co-ordinating the interactions of histone proteins with modification enzymes, nucleosome r...
متن کاملHistone chaperones regulate histone exchange during transcription.
Transcription by RNA polymerase II is accompanied by dynamic changes in chromatin, including the eviction/deposition of nucleosomes or the covalent modification of histone subunits. This study examined the role of the histone H3/H4 chaperones, Asf1 and HIR, in histone mobility during transcription, with particular focus on the histone exchange pathway, using a dual histone expression system. Th...
متن کاملHistone Chaperones: Functions beyond Nucleosome Deposition
Histones, the structural unit of chromatin, must be assembled/dissembled to preserve or change chromatin organization in accordance to cellular needs. Initially, function of histone chaperones was thought to be only “histone carriers/vehicles”, but now with accumulating evidences they are known to be the key actors of histone metabolism. With this outburst of knowledge, histone chaperones are n...
متن کاملFunctional conservation and specialization among eukaryotic anti-silencing function 1 histone chaperones.
Chromatin disassembly and reassembly, mediated by histone chaperones such as anti-silencing function 1 (Asf1), are likely to accompany all nuclear processes that occur on the DNA template. In order to gain insight into the functional conservation of Asf1 across eukaryotes, we have replaced the budding yeast Asf1 protein with Drosophila Asf1 (dAsf1) or either of the two human Asf1 (hAsf1a and hA...
متن کاملHistone Chaperones in the Assembly and Disassembly of Chromatin
Nucleosomes physically block access to the DNA, raising several questions (1) How are new nucleosomes formed in vivo? (2) How are nucleosomes removed to facilitate DNA templated processes? and (3) How are histones restored to the DNA following the completion of those processes? The intrinsic attraction between the negatively charged DNA phosphate backbone and the positively charged lysine and a...
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ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2012
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst20110737